Obesity and Cancer: Potential Mediation by Dysregulated Dietary Phosphate

Next to smoking, obesity is the second leading preventable risk factor for cancer, but increasing rates of and overweight are estimated overtake smoking as cancer factor. Few research studies have investigated dysregulated endocrine metabolism dietary phosphate a potential mediating in association with cancer. Phosphate toxicity, accumulation excess body from metabolism, associated tumorigenesis. High levels hormones that regulate such parathyroid hormone fibroblast growth 23, also obesity, providing link between toxicity. Increased intake inorganic linked excessive consumption foods processed additives, ultra-processed an increase incidence obesity. Sugar-sweetened beverages provide single largest source sugar energy U.S. population, colas containing phosphoric acid tumorigenesis, suggesting another connection Furthermore, positively correlated increases central metabolic syndrome. The present perspective article proposes potentially mediates